Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia
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چکیده
منابع مشابه
JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia
JAK2 abnormalities may serve as target for precision medicines in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In the current study we performed a screening for JAK2 mutations and translocations, analyzed the clinical outcome and studied the efficacy of two JAK inhibitors in primary BCP-ALL cells. Importantly, we identify a number of limitations of JAK inhibitor therapy. J...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2015
ISSN: 1535-6108
DOI: 10.1016/j.ccell.2015.06.005